From 1995-2001, I was Chair of one block of the curriculum (unit 2) in the Undergraduate Medical Program at McMaster University, Canada. Prior to that, I was a member of the Medical Admission Program and an Evaluation Co-ordinator in one of the Units. Because of the general interest in using problem-based learning (PBL) in medical education in the Asia Pacific region, I think it might be useful to share my experience with those who are interested in adopting PBL in their curriculum. In this article, an outline of the McMaster curriculum is given, followed by a description of the activities in Unit 2. A section on evaluation and a description of the administrative structure related to Unit 2 are given, because these are important aspects of making a Unit successful. Finally, under Reflections, I discuss aspects of tutor recruitment and training, integration of Unit 2 content, a new approach in providing learning resources, my views on evaluation, and the necessity of reform to reward excellence in education in a university setting.