Background: Recently, the applied physics course of the School of Medicine at Chung Shan Medical University was modified to meet the needs of medical education. The purpose of this study is to evaluate the effectiveness of improvements to the physics course in the School of Medicine by analyzing different questionnaire surveys conducted over four years. Methods: In 2014, modifications to this course were made to the content, teaching methods, and supplemental teaching approaches. This study analyzes the results of the questionnaire surveys conducted by Chung Shan Medical University from 2013 to 2015 and the School of Medicine from 2013 to 2016 to assess the effectiveness of the improvements to the course. Results: In total, 358 medical students participated in the questionnaire survey conducted by the university. Of them, 80.7%, 84.8%, and 93.9% concurred that the course materials helped improve learning effectiveness in 2013, 2014, and 2015 respectively. In total, 478 medical students participated in the survey conducted by the School of Medicine, and 78.8%, 86.9%, 98.6%, and 99.1% agreed that the course increased their understanding of fundamental physics principles and the application thereof in 2013, 2014, 2015, and 2016 respectively. Conclusion: The questionnaire survey on premedical education conducted by the School of Medicine reflected the impact of the modifications to the physics course on learning effectiveness. Appropriate modifications to the content and teaching methods of the School of Medicine's physics course can effectively improve teaching quality and enhance students' interest in studying physics.