薑黃素的生物效應

The Biological Effects of Curcumin

謝明祥(Ming-Xiang Xie) ； 黃文濤(Wen-Tao Huang) ； 林玴竹(Yi-Zhu Lin) ； 施科念(Ko-Nian Shih)

《元培學報》 15期 (2008/12) Pp. 1-10

https://doi.org/10.30171/JYUST.200812.0001

摘要

薑黃素(Curcumin)，是屬於薑科植物的一種，通常被使用在黃色染料和食品香料上。最近在許多文獻研究已證實薑黃素有許多的醫學特性，分別在動物實驗和分子生物研究皆能顯示出有抑制環氧化酶(cyclo-oxygenase-2; COX-2)和細胞激素(cytokines)達到抗發炎的作用，有能力抑制基質金屬蛋白酶(matrix metalprotease)的活性，減少對細胞外基質降解，避免腫瘤細胞侵襲到鄰近組織，並能調節Bcl-2和caspase的活化進而誘導癌細胞株凋亡，有抑制核因子κB(nuclear factor kappa B; NF-κB)和activating protein-1(AP-1)等轉錄因子的活化，減少發炎反應與腫瘤增生等生物效應。這篇文獻回顧主要描述薑黃素在動物實驗與分子生物研究上的化學預防效應與生物機轉。

關鍵字

薑黃素 ； 抗發炎 ； 抗腫瘤和核因子κB

並列摘要

Curcumin is one kind of Zingiber plant, usually used on yellow dyestuffs and food spices. It has already verified by many studies the curcumin has a lot of medical characteristics, and can be demonstrated in animal's experiment and molecular biological studies. Curcumin has the ability of anti-inflammation through suppressing cyclo-oxygenase-2 (COX-2) and cytokines, prevent tumor metastasis from blocking matrix metalproteases (MMP2 and MMP9), and can regulate the activation of Bcl-2 and caspases then induce cancer cells to apoptotic program. On the other hand, it can inhibit the transcriptional activation of nuclear factor kappa B (NF- kB) and activating protein-1 (AP-1), etc., reduce the biological effects of, such as inflammation, tumour hyperplasia, etc.. This document reviews and describes mainly that curcumins' chemoprevention effects and biological mechanisms in animal's experiment and molecular biological studies.

並列關鍵字

Curcumin ； Anti-inflammation ； Anti-tumor ； NF-B