Relationship Between Fasting Leptin and Insulin Concentrations in Type 2 Diabetes Mellitus Patients

第2型糖尿病病人瘦素與胰島素濃度的關係

張銀中(Ying-Chung Chang) ； 陳清助(Ching-Chu Chen) ； 簡誌銘(Chih-Ming Chien) ； 陳榮興(Rong-Hsing Chen) ； 王子源(Tzu-Yuan Wang) ； 張淳堆(Chwen-Tzuei Chang)

《Mid-Taiwan Journal of Medicine》 8卷1期 (2003/03) Pp. 1-7

https://doi.org/10.6558/MTJM.2003.8(1).1

摘要

Objectives: Many researchers have found that plasma leptin concentration is associated with insulin levels in non-diabetic subjects. However, the relationship between leptin concentrations and insulin levels in type 2 diabetes mellitus (DM) patients has rarely been investigated. The aim of this study was to investigate that relationship.
Methods: Fasting plasma glucose, fasting serum insulin (FSI), leptin concentration and body mass index (BMI) were measured in 100 type 2 DM subjects (50males and 50 females).
Results: There were no significant differences in age, BMI, fasting plasma glucose, FSI and HbAlc between male and female subjects. The mean leptin concentration of the female subjects was significantly higher than that of the male subjects (7.75 ± 6.41 vs 3.72 ± 3.70ng/mL, ρ＜ 0.01). Using Pearson correlation analysis, leptin concentration positively correlated with BMI (γ=0574, ρ＜ 0.001) and FSI levels (γ= 0.498, ρ＜ 0.001) in the male subjects. It also positively correlated with BMI (γ= 0.605, ρ＜ 0.001) and FSI levels (γ= 0.543, ρ＜ 0.001) but inversely correlated with age (γ = -0.399, P = 0.004) in the female subjects. After adjusting for age, BMI, and insulin modifying medications, FSI was significantly and positively related to leptin concentration (β= 0.180, ρ=0.031) in the male subjects but not in the female subjects (β= 0.131, ρ= 0.089). BMI also positively correlated with leptin concentrations in both genders after considering the effects of FSI and other covariates.
Conclusions: Leptin concentration significantly correlated with FSI levels in men with type 2diabetes but not in women with type 2 diabetes. The difference between the two groups may be due to age, gender effect, or other potential confounders. Further investigation is necessary.

關鍵字

胰島素 ； 瘦素 ； 第2型糖尿病

並列摘要

Objectives: Many researchers have found that plasma leptin concentration is associated with insulin levels in non-diabetic subjects. However, the relationship between leptin concentrations and insulin levels in type 2 diabetes mellitus (DM) patients has rarely been investigated. The aim of this study was to investigate that relationship.
Methods: Fasting plasma glucose, fasting serum insulin (FSI), leptin concentration and body mass index (BMI) were measured in 100 type 2 DM subjects (50males and 50 females).
Results: There were no significant differences in age, BMI, fasting plasma glucose, FSI and HbAlc between male and female subjects. The mean leptin concentration of the female subjects was significantly higher than that of the male subjects (7.75 ± 6.41 vs 3.72 ± 3.70ng/mL, ρ＜ 0.01). Using Pearson correlation analysis, leptin concentration positively correlated with BMI (γ=0574, ρ＜ 0.001) and FSI levels (γ= 0.498, ρ＜ 0.001) in the male subjects. It also positively correlated with BMI (γ= 0.605, ρ＜ 0.001) and FSI levels (γ= 0.543, ρ＜ 0.001) but inversely correlated with age (γ = -0.399, P = 0.004) in the female subjects. After adjusting for age, BMI, and insulin modifying medications, FSI was significantly and positively related to leptin concentration (β= 0.180, ρ=0.031) in the male subjects but not in the female subjects (β= 0.131, ρ= 0.089). BMI also positively correlated with leptin concentrations in both genders after considering the effects of FSI and other covariates.
Conclusions: Leptin concentration significantly correlated with FSI levels in men with type 2diabetes but not in women with type 2 diabetes. The difference between the two groups may be due to age, gender effect, or other potential confounders. Further investigation is necessary.

並列關鍵字

insulin ； Ieptin ； type 2 DM