Analysis of Test of Hemolytic Disease in Newborn with Neonatal Hyperbilirubinemia

From September 2000 to January 2004, 50 neonates received tests for hemolytic disease of newborn (HDN) due to hyperbilirubinemia. Twenty-two cases were HDN negative (-) and 28 HDN positive (+). In the HDN (-) group, most were premature babies. Excluding prematurity, there were no statistical differences in gender, peak bilirubin level, age at peak bilirubin level, number of babies requiring blood exchange transfusions (BET) or hemoglobin level at admission. In the HDN(+) group, ABO incompatibility accounted for 86% (24/28) of positive tests, and anti-A,B antibody was most frequently (17/28, 60.7%) eluted from the red blood cells (RBC) instead of pure anti-A and anti-B. Among the 10 cases receiving BET, 4 were HDN(+). These babies had an earlier peak bilirubin and lower hemoglobin level before BET than the HDN(-) babies receiving BET In these 4 cases, minor blood group incompatibilities due to E, c were most frequently encountered (3/4, 75%). In the 6 HDN (-) babies who required BET prematurity was the most likely etiology. BET was rarely required due to ABO incompatibility except when associated with other causes, which should be found out thoroughly.

並列關鍵字

test of hemolytic disease of newborn ； blood exchange transfusion ； blood group incompatibility ； neonatal hyperbilirubinemia

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