咀嚼木糖醇口香糖對唾液流速及氟離子濃度之影響

The Effects of Xylitol Chewing-gum on Salivary Flow Rate and Fluoride Concentration

簡珮怡(Pei-Yi Chien) ； 李坤宗(Kun-Tsung Lee) ； 黃純德(Shun-Te Huang) ； 林美能(Mei-Neng Lin) ； 李忠峯(Jong-Fong Lee) ； 賴辰雄(Chern-Hsiung Lai) ； 周振英(Chen-Ying Chou)

《Taiwan Journal of Oral Medicine Sciences》 24卷1期 (2008/04) Pp. 11-21

https://doi.org/10.7059/TJOMS.200804.0011

摘要

咀嚼口香糖可刺激唾液分泌，而本研究將評估木糖醇口香糖（甜味劑材料100%皆為木糖醇成分）和口香糖基(gum base)對唾液的影響。從28位健康者（20.07±0.20歲）中先收集未刺激的整個唾液(whole saliva)後，再蒐集咀嚼口香糖20分鐘的刺激性唾液，並將唾液樣本分為八個時段蒐集，兩種口香糖分別隔週咀嚼蒐集。測量每個樣本的唾液流速，並分析唾液pH值和唾液氟離子濃度。結果發現刺激性唾液流速於咀嚼初期（0-4分鐘）有顯著性差異，以木糖醇口香糖流速最快，後期（4-20分鐘）兩種口香糖刺激唾液效果相似。且刺激初期唾液流速增加為未刺激唾液流速的4-9倍，隨後刺激性唾液流速逐漸減緩，但最後時段仍高於未刺激性唾液流速2倍。咀嚼木糖醇口香糖與口香糖基時刺激性唾液pH值有立即增加情形，且增加至8-10分鐘達到高峰，隨後有輕微下降情形。兩組初期刺激唾液pH值提高效果相似，但後期約咀嚼8分鐘後，口香糖基顯著高於木糖醇口香糖。在未投予氟化物的狀況下，咀嚼口香糖刺激唾液分泌，兩組刺激性唾液氟離子皆有升高情形，且除了0-1分鐘和2-4分鐘之外，口香糖基的刺激性氟離子濃度大部分顯著高於木糖醇口香糖。故咀嚼木糖醇口香糖可刺激唾液流速增加和提高唾液pH值，具有正面影響。

關鍵字

木糖醇口香糖 ； 唾液流速

並列摘要

Gum chewing could stimulate a protective salivary flow. Therefore, we compared the effect of xylitol chewing gum (sweetening material is 100% xylitol, not sugar) and gum base on the salivary secretion of whole saliva. 28 healthy(20.07±0.20 years)subjects collected unstimulated whole saliva, and then, on different occasions, chewed xylitol chewing gum or gum base for 20 min, during which time eight separate saliva samples were collected. Flow rates were calculated and the saliva was assayed for salivary pH and fluoride concentration. Xylitol chewing gum stimulated the flow rate significantly higher than gum base during the initial stage (0-4 min)of chewing. By 4-20 min, both xylitol chewing gum and gum base were equally effective salivary stimulants. These initial stimulated flow rates averaged 4-9 times over the unstimulated rate, and then dropped progressively with time. The final stimulated flow rates were still about 2 times over the unstimulated rate. When chewing xylitol gum and gum base, the salivary pH rose immediately on stimulation, and reached peak during 8-10 min, then fell slightly with time. Stimulated salivary pH were similar in both groups at the beginning; but during 8-20 min, gum base chewing elicited pH higher than xylitol gum chewing. Chewing gum without fluoride, stimulated salivary fluoride rose immediately on stimulation, and stimulated salivary fluoride level of gum base was significantly higher than xylitol chewing gum, except in the 0-1 min and 2-4 min intervals. Hence, chewing of xylitol gum has positive effects which evoked stimulated flow rate and salivary pH.

並列關鍵字

Xylitol chewing-gum ； Salivary flow