Repeated application and removal of adhesive tapes may cause skin trauma at the wounds site or area of incision. The purpose of this study explores the learning effectiveness of hands-on practice of applying and removing adhesive medical products. The author used a pre-test and post-test design in the study for nurses to gain hands-on practice with wound care. The sample size was 78 subjects. A self-developed questionnaire and checklist were used to test the nurses' knowledge and skills. Collected data were analyzed using descriptive analysis, a paired t-test, and ANOVA. The results showed a significant difference in both the nurses' knowledge and skills after hands-on practice. However, there was no significant association between the nurses' background and knowledge and skills. The participants' satisfaction score for this program was 96.45 with a good response. This study encourages the use of hands-on practice in a performance-based instruction program in place of literature instruction as a method of clinical teaching.