”The Note of an Intern Doctor”, published in 1978, was written by Wang Yi-Cha, a graduate of medical department of National University. The writer, using the sensitive character of literature, narrates his thought and experience during he was an intern doctor. His introspection to modern medical science and the search of life is full of humanistic spirit. This article was described in the thought of humanity. The research and thinking process of this article were based upon the clues provided in Dr. Wang's book, including experience of the hard circumstance of life and the introspection to medical education while he was on his way to become a practical physician. In addition, we analyzed and observed the impact of diseases in physiological and mental aspects, based on author's viewpoint of ”uncertainty in medical science” and ”the meaning of life”. The relationship and connection between the current prose in medicine and this book were also discussed at the end of this article.