According to the problematique of causation in philosophy, this paper aims to explore how to debate the questions of causation with Samkhya and Vaiśeşika in Āryadeva's Śataśāstra(百論), and presents important insights on causation in Madhyamaka. After an inquiry into questions of causation in the history of philosophy, this paper mainly rebuts causation of active things (有爲法) in Śataśāstra by re-examining (a) important causal conceptions generally discussed in the three śāstras, (b) effect implied in cause, focusing on the cause-effect relationship, and (c) effect not implied in cause, highlighting the meaning of ”to produce” in causation.