Hepatitis C Virus Infection and Metabolic Syndrome-A Community-Based Study in an Endemic Area of Taiwan

C型肝炎感染與代謝症候群－一個台灣C型肝炎高盛行地區之社區研究

黃志富(Jee-Fu Huang) ； 莊萬龍(Wan-Long Chuang) ； 余明隆(Ming-Lung Yu) ； 余松樺(Sung-Hua Yu) ； 黃釧峰(Chung-Feng Huang) ； 黃駿逸(Ching-I Huang) ； 葉明倫(Ming-Lun Yeh) ； 謝孟軒(Meng-Hsuan Hsieh) ； 楊正福(Jeng-Fu Yang) ； 林子堯(Zu-Yau Lin) ； 陳信成(Shinn-Chern Chen) ； 戴嘉言(Chia-Yen Dai) ； 張文宇(Wen-Yu Chang)

《The Kaohsiung Journal of Medical Sciences》 25卷6期 (2009/06) Pp. 299-305

摘要

Metabolic syndrome (MS) is a complicated disorder associated with a high risk of future development of micro-and macrovascular complications. The extrahepatic manifestations of hepatitis C virus (HCV) infection can include multiple metabolic abnormalities. However, the extent, severity, and characteristics of MS in HCV-infected patients have rarely been investigated in community-based settings. This study aimed to determine the difference in prevalence and distribution of the components of MS between HCV-infected patients and healthy controls. Multipurpose mass screening of adults was conducted in an HCV-endemic area of Southern Taiwan. Clinical profiles in terms of anthropometric data and MS components, as well as viral hepatitis markers, were assessed. Two hundred and thirty-seven adults (94 males; mean age, 55.5±10.8 years) were recruited. The prevalence of anti-HCV seropositivity was 39.2% (93/237). The prevalence of MS was higher in the HCV-infected individuals (24.7%, 23/93) than in the control, uninfected subjects (13.2%, 19/144, p-0.02). In terms of MS components, HCV-infected subjects had a higher prevalence of high waist circumference (51.6% vs. 25.7%, p＜0.001) and hypertension (58.1% vs. 36.8%, p-0.001) than controls. Multivariate logistic regression analysis demonstrated that anti-HCV positivity was significantly associated with MS (odds ratio, 6.4; 95% confidence interval, 1.82-22.84; p-0.004). HCV infection was associated with a higher prevalence of MS. Determination of MS in patients with HCV infection could therefore be indicated.

關鍵字

C型肝炎 ； 胰島素耐受性 ； 代謝症候群

並列摘要

Metabolic syndrome (MS) is a complicated disorder associated with a high risk of future development of micro-and macrovascular complications. The extrahepatic manifestations of hepatitis C virus (HCV) infection can include multiple metabolic abnormalities. However, the extent, severity, and characteristics of MS in HCV-infected patients have rarely been investigated in community-based settings. This study aimed to determine the difference in prevalence and distribution of the components of MS between HCV-infected patients and healthy controls. Multipurpose mass screening of adults was conducted in an HCV-endemic area of Southern Taiwan. Clinical profiles in terms of anthropometric data and MS components, as well as viral hepatitis markers, were assessed. Two hundred and thirty-seven adults (94 males; mean age, 55.5±10.8 years) were recruited. The prevalence of anti-HCV seropositivity was 39.2% (93/237). The prevalence of MS was higher in the HCV-infected individuals (24.7%, 23/93) than in the control, uninfected subjects (13.2%, 19/144, p-0.02). In terms of MS components, HCV-infected subjects had a higher prevalence of high waist circumference (51.6% vs. 25.7%, p＜0.001) and hypertension (58.1% vs. 36.8%, p-0.001) than controls. Multivariate logistic regression analysis demonstrated that anti-HCV positivity was significantly associated with MS (odds ratio, 6.4; 95% confidence interval, 1.82-22.84; p-0.004). HCV infection was associated with a higher prevalence of MS. Determination of MS in patients with HCV infection could therefore be indicated.

並列關鍵字

hepatitis C virus ； insulin resistance ； metabolic syndrome