Synchronous Primary Ovarian Sertoliform Variant of Endometrioid Adenocarcinoma and Primary Endometrial Well Differentiated Endometrioid Adenocarcinoma

同時發生的Sertoli變異型卵巢原發子宮內膜腺癌與分化良好的子宮原發內膜腺癌

黃麗菁(Lai-Ching Wong) ； 林偉隆(Wea-Lung Lin) ； 陳進典(Gin-Den Chen) ； 許振東(Jeng-Dong Hsu) ； 郭智(Chee Kuo) ； 張菡(Han Chang) ； 曾楨皓(Chen Howard Tseng)

《中山醫學雜誌》 14卷2期 (2003/05) Pp. 327-333

https://doi.org/10.30096/CSMJ.200305.0014

摘要

子宮內膜樣的癌瘤，在惡性上皮性卵巢腫瘤中佔了百分之十到百分之二十。而其Sertoli氏變異型相當罕見，過去的文獻中只報告過二十三例。於此報告的病例，是一位八十四歲的女性病人，其卵巢具有Sertoli氏子宮內膜樣的癌瘤，同時在子宮內膜亦有一分化良好的子宮內膜上皮癌。在卵巢腫瘤的組織病理變化方面，現出類似Sertoli細胞的小腺管狀構造，而其皮膜抗原(EMA)及細胞角蛋白-8(CK-8)的免疫染色都呈陽性，CD99的免疫染色則只有微弱的細胞漿顆粒狀的陽性反應。此病例是首例被報告的卵巢Sertoli氏 子宮內膜樣癌瘤，同時在子宮合併原發的內膜樣癌瘤。

關鍵字

細胞角蛋白-8 ； 子宮內膜樣癌瘤 ； Sertoli氏變異型

並列摘要

Endometrioid carcinoma accounts for 10 to 20 percent of ovarian carcinomas. With only 23 cases reported in the literature, its sertoliform variant is rare. We report here the case of an 84-year-old female with the rare variant of ovarian endometrioid adenocarcinoma simulating a Sertoli cell tumor with a synchronous well-differentiated endometrioid adenocarcinoma of the endometrium. On histopathologic examination, small tubular structures resembling Sertoli cell tumors were found in the ovarian neoplasm. These stained positively for epithelial membrane antigen (EMA) and cytokeratin-8 (CK-8) a low molecular weight cytokeratin. There was also weak cytoplasmic granular staining pattern for CD99. A well-differentiated endometrioid carcinoma was present in the endometrium. This is the first reported case of ovarian sertoliform endometrioid carcinoma combined with endometrial endometrioid carcinoma.

並列關鍵字

CK-8 ； Endometrioid carcinoma ； EMA ； sertoliform variant