Several researchers have claimed that socio-cultural concepts and rituals that surround natural phenomena can shape students' conceptions in the learning of science However, the conceptions held by native students arc typically ignored or purposefully denied in the traditional teaching of science at school. Trends in science education have determined that the native science curriculum and instruction should situate the students' learning of science in its appropriate socio-cultural contexts, including the students' lifestyles and traditions. Over the past two decades, in other countries, many sets of programs, guidelines or frameworks have situated native students' learning of science in the native socio-cultural contexts. Grade 1-9 Curriculum Reform in Taiwan has focused on developing school-based curriculum with community participation and integrated curriculum design as critical components in effective learning. Within the framework of Grade 1-9 curriculum Reform native science curriculum and instruction can accommodate multiple socio-cultural context, lifestyles and traditions as well as the participation of community The study argues that the framework of Grade 1-9 Curriculum Reform develops the native science curriculum and instruction according to native life experience in native socio-cultural contexts, Examining the primary issues in native science education in Taiwan, relevant research, the philosophy of the Grade 1-9 Curriculum Reform ,and other countries' experiences, this study proposes suggestions for use in the science curriculum and for the instruction of native students in Taiwan. A learning unit is also presented to illustrate a concrete process within a socio-cultural1y orientated science curriculum and instruction for native students, The unit teaches concepts around sound waves by using indigenous tribes' traditional musical instruments