Clinical nursing staff establish professional commitment and career goals through professional development. The main purposes are for life-long learning, professional role and function expanding, promoting health care service quality and advanced career development. The major themes of this paper will explore relationships between professional socialization, professional commitment and professional career development. Contents include the following subjects: (1) Present the definitions and relations between professional socialization, professional commitment and professional career development. (2) Introduce career pathways of professional development and a nursing development model. The authors hope to help clinical nursing staff not only to establish goal-oriented and meaningful professional career, but also to assist nursing staff development and health care quality.