This article described a nursing experience of a patient infected with cryptococcus meningitis and diagnosed with acquired immune deficiency syndrome(AIDS), which triggered physiological and psychological impacts. The caring period was from January 27 to February 14, 2011. Gordon's functional health assessment tool was applied to assess the patient's condition via the data collected from clinical care, physical assessments, observations and interviews. Three health-related problems were identified: existing infection, social isolation, and malnutrition. During the nursing process, nursing interventions were implemented, which included: easing the discomforts of infection by providing surgical mask; modifying hand washing skill and teaching the patient not to ingest raw food and water; actively care for the patient and apply empathy skills; leading interactions among the patient and family members via body language; improving social relationships by encouraging a positive attitude, and reducing the negative impacts experienced by the patient after contracting AIDS by providing mouth gargling to maintain oral hygiene and offering nutrition education. The author hoped to provide this nursing experience as a clinical reference for nursing staff when taking care of AIDS patients in the future.