- 期刊
利用多次短閉氣正子照影改善呼吸假影對位誤差
Clinical Application of the Multi-Breath-Hold PET/CT Image to Improve Respiratory Motion Artifact
摘要
呼吸假影對於正子電腦斷層照影一直是個長久以來的問題，近年部分研究也陸續提出解決方案，不論是採用平均電腦斷層方式（average CT）或是4D正子電腦斷層採集等等，其中創新的研究指出採用閉氣方式可以進一步改善影像品質，然而閉氣時間過長對於癌症受檢者之配合度影響甚大。本研究利用呼吸監控系統進行多次短閉氣（multi-breath hold, Multi-BH）正子電腦斷層影像來改善影像品質，研究共計34名受檢者41處懷疑病灶，其中影像採集後對於病灶有對位不佳、標準攝取值（standardized uptake value, SUV）異常與偽陽性排除等疑慮時，採用多次短閉氣照影，採集過程無任何額外劑量僅增加正子影像收取時間，並比較多次短閉氣方式與傳統自由呼吸方式（free-breath, FB）之影像對位與定量分析差異。研究發現多次短閉氣正子影像有效的改善傳統影像收取方式，除了電腦斷層影像因閉氣方式可得到較清晰影像外，影像位移誤差與SUV_(max)定量上有顯著差異顯著性（P＜0.001）。多次短閉氣正子照影能改善影像品質、影像對位與定量分析，給予醫師最佳的判讀影像。
並列摘要
Impact of respiratory motion to quantitation of the PET/CT image has been reported. However, most studies proposed a 30 to 40 sec deep-inspiration breath-hold (DIBH), which is difficult for patients to complete. In this study, we designed a clinically practical protocol of multi-breath-hold (Multi-BH) PET/CT to improve quantitation based on multiple 15-sec BHs. We recruited a cohort of 34 patients in this study. The same patient was scanned the whole-body PET/CT and Multi-BH. The Multi-BH scan data were summed to increase the statistics of the study. All scans were conducted on the Siemens Biography MCT scanner. The respiratory monitoring device was the AZ-733V (Anzai Medical Co. Ltd) to ensure the BH position and was maintained during the DIBH scan by the patient. Comparison of the motioning distance and maximum standardized uptake value (SUV_(max)) from BH with the baseline free-breathing (FB) PET was made. The study included 41 lesions from 34 patients. There were mis-alignments between the CT and the PET images on nine lesions for the FB PET, and one lesion for the Multi-BH PET. The motioning distance and SUV_(max) values of the Multi-BH images were significantly different with the SUV_(max) values of the FB whole-body PET/CT scans (P＜0.001). The average SUV_(max) increase was 60%. Using a series of 15-sec Multi-BH PET scans can improve the quantitation of PET/CT image and the image alignment.
延伸閱讀
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- 邱韋桓（2013）。同步監控與改善呼吸位移之補償裝置驗證〔碩士論文，國立臺北科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0006-0808201300404800
- Liu, F. S., Ko, C. L., & Yen, R. F. (2020). 呼吸位移校正改善心肌灌注影像的判讀. 核子醫學暨分子影像雜誌, 33(3), 189-193. https://doi.org/10.6332/ANMMI.202009_33(3).0007
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