Superior mesenteric artery syndrome is an uncommon cause of duodenal obstruction. We present a case of 60-year-old woman with complaints of epigastric fullness and vomiting after surgery for sigmoid cancer. Rapid weight loss from 55 to 45 kg was noted during the perioperative period. Hypotonic duodenography showed an abrupt filling defect at the third portion of the duodenum and abdominal ultrasound revealed a narrow aortomesenteric angle. Total parenteral nutrition was supplied and the symptoms subsided with weight gain. Follow-up duodenography revealed the smooth passage of contrast through the duodenum. We conclude that conservative treatment for SMA syndrome is adequate and effective if the predisposing factors are corrected.