A 54-year-old man was admitted with irregular abdominal cramps, with pain in his epigastrium. He had no diarrhea, nausea, or vomiting. Panendoscopy revealed reflux esophagitis and a duodenal ulcer. The results of laboratory tests were normal, but a computed tomography scan of his abdomen indicated that he had a large round mass on the right side of his lower abdomen. We performed laparotomy, and we found an ileocecal intussusception with a tumor. The tumor was located at the ileocecal valve and was involved with the cecal wall. The right hemicolon, which contained the tumor, was resected. Histological examination revealed large lymphoma cells that had infiltrated the deep muscular layer. The tumor stained positive for CD-20 but negative for CD-3 and cytokeratin. Based on these data, we diagnosed the uncommonly reported condition of adult intussusception caused by malignant lymphoma.