The Pop Art has the interesting and popular characteristic that reflects the current urban life. Thus, designers of most major A-list brands, no matter for read-to-wear, furniture and accessories, always use ”Pop Art” style as their inspiration for their works. The feature of the Pop Art is with several bright colors, the form of art commercialization, general public culture and using ironic and metaphor methods to express the concept of creation. It has quite special and long-term influence on fashion industry. The study focuses on the origin, features, spirits and theme of the Pop Art by referring to related documental references, and applies the Pop Art style on the make-up design. It also adopts the color mixing and the essence of the Pop Art to create five different styles of make-ups, and presents the symbolization of the Pop Art.