Toxins and Other Bioactive Compounds Produced by Cyanobacteria in Lake Ladoga

Tsüanobakterite poolt produtseeritavate toksiinide ja muude bioloogiliselt aktiivsete ühendite mitmekesisus Laadoga järves

Ludmila Voloshkoa ； Jiri Kopecky ； Tatiana Safronova ； Alla Pljusch ； Nina Titova ； Pavel Hrouzek ； Valentina Drabkova

《Estonian Journal of Ecology》 57卷2期 (2008/06) Pp. 100-110

並列摘要

Biologically active compounds were detected in water blooms on Lake Ladoga for the first time. Screening for cytotoxicity and for trypsin and acetylcholinesterase inhibitors revealed a degree of inhibitory activity by the water bloom biomass, which indicates the presence of cyanobacterial toxins in Lake Ladoga. High performance liquid chromatography (HPLC) of extracts of selected samples from the lake demonstrated a rather high diversity of bioactive compounds including hepatotoxic cyclic peptides (microcystins), enzyme inhibitors (cytotoxins), and a series of unidentified substances. Thirteen toxins and protease inhibitors were identified by the HPLC. The toxins were most diverse in the most eutrophic southern part of the lake (up to 12 bioactive compounds). Chromatograms showed that planktopeptin BL dominated in most of the samples investigated, except those from Svir Bay, where mcyst-LR prevailed. The results obtained indicate anthropogenic eutrophication of Lake Ladoga and a decrease in water quality. This lake is used as the only source of drinking water for the city of St. Petersburg.

並列關鍵字

Lake Ladoga ； cyanobacteria ； toxin diversity