- 期刊
Comparison of Plasma Levels of Free Amino Acids in Premature Infants at 1 and 3 Days of Life
早產兒於出生第一天及第三天血漿中氨基酸濃度之比較
摘要
在懷孕末期，胎兒要經過一個快速的成長及儲存體內的蛋白質和其他營養的過程。但早產兒無法儲存這些營養，所以出生後在無法經腸胃道進食的情況下，就需要早期補充這些營養劑。而這研究的目標是要探討早產兒在禁食時第一天注射葡萄糖及第三天注射葡萄糖加電解質時血漿內氨基酸的變化。結果顯示氨基酸內有以下essential amino acids: lysine and arginine、conditionally essential amino acids: cysteine, and nonessential amino acids: proline、alanine and glutamine偏低。同時non-essential amino acids: glutamic acid.則顯示增加。因此早產兒在無法經腸胃道進食時早期氨基酸的補充是必要的。
並列摘要
During the third trimester of pregnancy, the fetus undergoes rapid growth and accumulates body nutrients. But premature newborns are unable to store nutrients, and therefore early nutritional supplements are required especially if neonates cannot tolerate enteral feeding. The objective of this study was to analyze changes in plasma free amino acid levels on the first and third days of life, when the premature babies were on NPO and received intravenous glucose water on day 1 and a glucose-electrolyte infusion on day 3. Totally, there were 14 premature infants whose baseline characteristics (mean±1SD) were a gestational age of 30±3.2 weeks, birth bodyweight of 1.1±0.3kg, birth body height of 36.5±3.1cm, birth head circumference of 26.3±2.6cm, and Apgar scores of 4.9±1.9 at 1 min and 7.4±1.3 at 5min. A Beckman 6300 amino acid analyzer was used to analyze plasma amino acid levels. Mann-Whitney U statistical analysis was used for data analysis. Results in these premature infants showed significant decreases in plasma levels of the essential amino acids, lysine and arginine, of the conditionally essential amino acid, cysteine, and of the non-essential amino acids, proline, alanine, and glutamine. In contrast, a significant increase in glutamic acid was noted. Therefore, early parenteral supplementation of amino acids is required in premature infants who cannot tolerate enteral feeding.
延伸閱讀
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