A series of phenolic amides has been prepared. The inhibition of Cu(superscript 2+)/O2-induced low density lipoprotein (LDL) lipid peroxidation activity and direct scavenging effect on 1,1 -diphenyl-2-picryl hydrazyl (DPPH) of these phenolic amides have also been evaluated. The results showed that compounds 9 and 15 were strong inhibitors of lipid peroxidation, and compound 1 was the most potent compound on DPPH radical scavenging assay.