This study, first, explores the preference degree of consumers for advertising spokesperson and the advertising effects of spokesperson from the marketing strategy of fast-food chain store and they influence the consumers’ willingness to buy. Second, how the gender's difference of spokesperson influences the consumers' willingness to buy is also be investigated. This study finds that it is significantly and highly relevant among preference degree, willingness to buy and advertising effect. The research of the difference analysis discovers that the 'preference degree', 'advertising effects', willingness to buy' of female consumers for advertising spokesperson are higher than males. There is significantly difference for different sex to the 'preference degree' of male advertising spokesperson; especially, women are higher than man for preferring the male spokesperson. On the other side, no matter what is the gender of spokesperson, the effects of advertising spokesperson on the female consumers are better than males.