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慢性萎縮性胃炎與癌前病變之綜述

Chronic Atrophic Gastritis and Pathological Changes Prior to Cancer

摘要


慢性萎縮性胃炎是臨床常見的消化道疾病,是胃黏膜在組織病理學上的實質性病變,為胃炎的一種類型。臨床主要表現為上腹隱痛、食欲減退、食後飽脹、噯氣等,屬中醫學“胃脘痛”、“胃痞”等範疇,具有反覆發作、遷延難愈的特性。1978年WHO將慢性萎縮性胃炎列為胃癌的癌前狀態,而在其基礎上伴發的腸上皮化生(Intestinal metaplasia,IM)和域異型增生(DYSplasia, DYS),則與胃癌的發生關係密切,被視為癌前病變(Precacerous lesions Of gastric cancer, PLGC)多年來始終是臨床及病理學研究的重點。

並列摘要


Chronic Atrophic Gastritis is a common clinical digestive disease with substantial changes of gastric mucous lining in tissue pathology. Clinical manifestations are soreness on epigastric region, decreased appetite, distention after meal and eructation. It belongs to ”epigastric pain” and ”Stomach Pi syndrome” in TCM with characteristics of repetition and pertinacity. In 1978, WHO listed chronic atrophic gastritis as precancerous lesions of gastric cancer because its complications of intestinal metaplasia and dysplasia are closely related to gastric cancer. This has been a research focus in clinical practice and pathology for years.

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