A 31-year-old female took high dose of immunosuppressive agents due to refractory psoriasis for almost twenty years. Besides, she also had right side ovarian endometrioma and received two times operation but the ovarian endometrioma was still recurrent. Due to poor control of psoriasis and ovarian endometrioma, she went to our Chinese Medicine OPD for help. Through around three years of treatment and follow-up, the condition of psoriasis and ovarian endometrioma got stable control and great improvement. We demonstrated the experience in this case report for clinical reference and application.