This case is a 38-year-old female. In the past year (since 109years), the acne around the neck and chin has worsened, and she has experienced poor sleep and easy to wake up five years ago. At the beginning of this year (110.1), the situation of constipation has changed. Severe, and accompanied by many premenstrual syndromes, such as lighter premenstrual sleep, headache, lower abdominal pain, increased constipation, and more menstrual blood clots and other gynecological symptoms. The common TCM syndromes of acne are mostly heat syndrome and empirical evidence, but not all acne diseases belong to the excess heat syndrome. The patient reported in this case is acne with deficiency-cold syndrome. One of the prescriptions used to treat syndromes of spleen-yang deficiency. After more than three months of traditional Chinese medicine treatment, the patient's acne has not recurred, and the problem of insomnia has also improved a lot. Therefore, a case report is specially written here for clinicians' reference.