川芎嗪在心腦血管方面的藥理作用與研究進展

Pharmacological Research and Development of Tetramethylpyrazine in the Role of Cardiovascular and Cerebrovascular

高宗桂(Tsung-Kuei Kao) ； 梁淑梅(Su-Mei Liang)

《臺灣中醫科學雜誌》 5卷2期 (2011/02) Pp. 58-68

https://doi.org/10.29810/SJTTCM.201102.0008

摘要

目的：綜述川芎嗪(Ligustrazine, LT)對心腦血管作用的藥理學研究進展。方法：查閱近年來有關文獻，進行歸納總結。結果：川芎嗪能夠擴張心血管、保護冠脈內皮、促進心肌細胞能量代謝、鈣拮抗作用抗血小板聚集和血栓形成等。在腦血管方面有顯著減輕腦缺血再灌注損傷後血管內皮細胞與白血球的黏附作用，對缺氧缺血性腦損傷具有保護作用。能夠影響腦缺血再灌注後神經細胞凋亡及調控凋亡相關基因腦組織Fos蛋白表達、c-jun蛋白表達與Bcl-2蛋白表達、影響NOS的變化。結論：川芎嗪具有多種藥理作用，廣泛用於心腦血管疾病的治療。

關鍵字

川芎嗪 ； 心血管 ； 腦血管，藥理作用 ； 機轉

並列摘要

Objective: To review the pharmacological research of TMP (Ligustrazine, LT) in the role of cardiovascular and cerebrovascular. Methods: The relevant literature in the recent years is summarized. Results: TMP to expand cardiovascular, coronary endothelial protection, to promote metabolism of myocardial energy, calcium antagonism on platelet aggregation and thrombus formation. Blood vessels in the brain has significantly reduced cerebral ischemia-reperfusion injury of vascular endothelial cells and leukocyte adhesion effect, to show protection on the hypoxic- ischemic brain injury in rats. TMP affect the ischemia-reperfusion of cerebrovascular in neuronal apoptosis and apoptosis-related gene regulation of Fos protein expression in brain tissue, c-jun protein expression and Bcl-2 protein expression of NOS changes. Conclusion: TMP has variety of pharmacological effects, widely used in the treatment of cardiovascular and cerebrovascular disease.

並列關鍵字

tetramethylperazine ； cardiovascular ； cerebrovascular ； pharmacological effect ； Mechanism