Family-centered care is an important concept of nursing. Although many scholars have developed theories of family nursing, many nursing theories have also defined clients from individuals to families and communities. However, clinical nurses still lack a solid knowledge foundation for the theoretical and clinical applications related to family nursing, as well as methods for clinical application since many years. The philosophy of family-centered care has also been advocated for many medical professional organizations in various fields. However, there is still a gap from theory to research and to practice. This article introduces the general family nursing theories and explores level one empirical literature through an evidence-based approach to understand the evidence basis of family-centered care at this stage. Finally, it proposes the future direction and recommendations for family nursing in education, research, and practice.