Olfactory Neuroblastoma - A Case Report

嗅神經母細胞瘤之病例報告

陳鴻鑫(Hong-Shin Chen) ； 林巧峯(Frank Cheau-Feng Lin) ； 李佳茹(Chia-Ru Li) ； 蔡青劭(Stella Chin-Shaw Tsai)

《童綜合醫學雜誌》 10卷1期 (2016/06) Pp. 41-45

摘要

嗅神經母細胞瘤是一種罕見鼻竇鼻腔惡性腫瘤，臨床症狀並沒有特異性，需仰賴病理組織報告確診，常見的症狀有鼻塞、流鼻血、嗅覺喪失等。本院於2013年經歷一嗅神經母細胞瘤病例，依據Kadish分期為C期，根據TNM系統則為第四期（T4N0M0）。經解釋後病人接受經鼻內視鏡手術治療，並於術後安排病患接受同步化學與放射線治療。病患接受完整治療後，再次接受MRI檢查，發現腫瘤已消除，並於治療後半年及1年，接受MRI追蹤檢查，顯示腫瘤並無復發。因嗅神經母細胞瘤病例並不多，特提出報告，並就病理分期、臨床分期及治療方式加以討論。

關鍵字

嗅神經母細胞瘤 ； 手術治療 ； 存活率

並列摘要

Olfactory neuroblastoma is a rare sinonasal malignant tumor which often presents with non-specific clinical symptoms as nasal obstruction, epistaxis, or anosmia. The diagnosis of olfactory neuroblastoma requires pathologic examination. In 2013, we encountered a case of olfactory neuroblastoma classified as Kadish stage group C, and T4N0M0 stage IV. After lengthy discussion, the patient underwent transnasal endoscopic biopsy and concurrent chemoradiotherapy. The post-treatment MRI showed shrinkage of the tumor. Follow-up MRI at 6 months and 1 year after treatment showed no evidence of tumor recurrence. As olfactory neuroblastoma is a relatively uncommon disease, we reported this case and discussed the pathological staging, clinical staging and treatment modality.

並列關鍵字

Olfactory neuroblastoma ； Surgery ； Survival