The purpose of this study was to explore the effects of a multimedia American Sign Language (ASL) software on helping culturally disadvantaged elementary students to learn ASL and English. The multimedia software includes ASL manual alphabet, initialized signs, and English words with different colors to differentiate syllables. A counterbalanced design was used to assess the difference between two teaching strategies: teaching alphabetically and teaching by similar meanings. The latter was found to be better than the former significantly. Students' spelling of English words also improved by more than two times from pretest to posttest.