Based on the idea of a comprehensive enterprise inventory management, the inventory cost, inventory control experience, the optimization of inventory system management and the results of previous studies were analyzed, using inventory management concepts and methods of advanced enterprises, to large manufacturing enterprise as the core research object, on the set of suppliers, manufacturers, distributors for the integration of the supply chain as the foundation the research framework, using the supply chain system theory as research method, analysis of the inventory management present situation, affecting factors and reasons, put forward the corresponding countermeasures of inventory control from the optimization of production management, the integration of internal supply chain and inter enterprise supply chain perspective, in order to achieve inventory optimization of comprehensive, improve operational efficiency.