This research was aimed to analyze food additives by infrared spectrum (IR) and Raman spectrum since 2010. We also set up the technique of X-ray diffraction (XRD) in 2011 to improve the capability for the analysis on nontargeted compounds. This nontarget analysis technique was employed to some case studies in 2011, such as finding unknown phthalate in cloudy agent by IR and Ramon spectra, finding 2-chloroethanol in rice wine by Ramon spectrum, characterizing the structure of magnesium oxide in probiotics dietary supplement by X-ray diffraction analyze, etc. We shall be able to apply these techniques to carry on the analysis of the unknown compounds in the future.