利用氧相層析質譜法同時分析化粧品中十種鄰苯二甲酸酯類成分

Simultaneous Determination of Ten Kinds of Phthalate Esters in Cosmetics by GC/MS

鄭淑晶(Shu-Ching Cheng) ； 黃守潔(Shou-Chieh Huang) ； 陳玉盆(Yu-Pen Chen) ； 闕麗卿(Lih-Ching Chiueh) ； 施養志(Daniel Yang-Chih Shih)

《食品藥物研究年報》 4期 (2013/11) Pp. 308-318

摘要

本計畫擬利用氣相層析質譜法，建立一種簡單、快速，能同時分析化粧品中dibutyl phthalate （DBP）、bis（2-methoxyethyl）phthalate（DMEP）、diisopentyl phthalate（DiPP）、di-n-pentyl phthalate（DnPP）、benzyl butyl phthalate (BBP)、bis (2-ethylhexyl) phthalate（DEHP）、di-n-octyl phthalate（DnOP）、diethyl phthalate(DEP)、dimethyl phthalate (DMP)、di-isobutyl Phthalate（DiBP）等10種鄰苯二甲酸酯類成分之檢測方法。檢體以甲醇溶解並定容離心後，以氣相層析質譜儀進行分析，層析管柱使用被覆5%phenyl-95%methylpolysiloxane之HP-5MS毛細層析管（30 m × 0.25 mm，0.25μm），並採用氦氣為移動相氣體，以電子撞擊游離法偵測。10種鄰苯二甲酸酯類成分線性範圍介於0.26-11.60 μg/mL，迴歸直線判定係數（coefficient of determination；r^2）均介於0.9985-0.9999。

關鍵字

化粧品 ； 鄰苯二甲酸酯類 ； 氣相層析質譜法

並列摘要

This study is to establish a simple and rapid method that could detect ten kinds of phthalate esters in cosmetics simultaneously. A gas chromatography-mass spectrometry method was developed to determine dimethyl phthalate, diethyl phthalate, di-iso-butyl phthalate, di-n-butyl phthalate, bis (2-methoxyethyl) phthalate, di-iso-pentyl phthalate, di-n-pentyl phthalate, benzyl butyl phthalate, di (2-ethylhexyl) phthalate and di-noctyl phthalate. Cosmetic samples spiked with internal standard solutions were extracted with methanol by ultrasonication and the analytes were separated using a capillary column. The regression coefficients (r^2) of the ten standard curves were between 0.9985 - 0.9999 and the linear ranges were between 0.26-11.60 μg/mL.

並列關鍵字

phthalate esters ； GC/MS ； cosmetics