Aging is a gradual, continuous process of natural change that usually begins during middle life, and is characterized by many bodily functions that begin to gradually decline. Environment, dietary and lifestyle are probably major factors influence susceptibility to many diseases. These factors may result in high risk of chronic diseases, and even premature death. Thus it is important to have a life course perspective of chronic diseases and risk factors which recognize the interactive and cumulative impacts of social environment and biological influences throughout life. Being physically active plays an essential role on improving health and reducing risk factors for chronic diseases. However, the body function and physiological situation in middle-aged and older people should be considered, At last whether less physical activity than the recommended three times a week can have life expectancy benefits is needed further research.