Interdisciplinary refers to teachers, school children, or disciplines in more than two different fields, and under the common planning objectives, with the coordinated approach of helping, learner is more likely, breakthrough, and innovative than the students learning in a single subject. The main purpose of this study was to analyze the learning effectiveness of the interdisciplinary learning courses. Through quasi-experimental research design, the study found that the use of interdisciplinary learning, significantly improved students' learning effectiveness, learning motivation, and learning attitude. Compared with the same disciplinary learning, interdisciplinary learning more significantly improves students' learning performance.