"Fu Qingzhu gynecology", written by Fu Qing Zhu at the end of Ming dynasty, is a fine detailed and original monograph for treating gynecologic diseases. "Fu Qingzhu gynecology" was compiled strictly and recorded treatments based on different syndromes and many prescriptions. The academic thoughts of "Fu Qingzhu gynecology.Zhongzi Conception" in treating infertility were analyzed in this study which includes pathogenesis, academic origin, treatment, frequency and dose of drug use. Fu Qing Zhu considered "spleen and kidney" and "conception vessel, governor vessel, and belt vessel" as the core of treating infertility. Qing Zhu often prescribed "Bai Zhu", "Ginseng" and "Ba Ji Tian" for treating infertility. Moreover, Qing Zhu often used supplementation and astriction method for treating infertility. Fu’s treatment in infertility not only inherited the tradition, but also got distinct experiences, which are worthy to learn and application in clinic.