目的:透過整理、分析《傅青主女科》治療婦女情志致病所用方藥,闡明用藥特點、配伍規律與關聯分析。方法:本文收集《傅青主女科》治療婦女情志致病內服方藥,利用Excel表單統計藥物分佈頻數。針對高頻用藥使用Apriori演算法進行關聯分析,找出高關聯藥物組合,再使用Gephi軟體進行網絡分析,找出核心用藥與新模組。結果:《傅青主女科》治療婦女情志致病用方之高頻中藥有當歸、白芍、白朮、甘草、柴胡、牡丹皮、熟地黃、人參、黑芥穗;功效分類多補益、理血與清熱藥;藥性多溫、微寒、平性;藥味多辛、苦、甘味,歸經多脾、肝經。有八組高關聯藥物組合。核心用藥為白芍、人參、熟地黃、白朮、當歸、柴胡、香附、牡丹皮,並發現兩個新模組:(1)白朮、人參、陳皮、川芎;(2)白芍、熟地黃、當歸、茯苓。結論:藉由分析《傅青主女科》婦女情志致病方藥,可以見到傅氏治療以補益為主,祛邪為輔。核心藥物取逍遙散疏肝解鬱、健脾養血之意。兩個新模組分別用於肝火引動致脾虛難以制血之症與血虛明顯之症,可以作為中醫師治療婦女情志致病的辨證論治與臨床加減之參考。
Objective: To analyze the prescriptions used to treat women's emotional diseases in Fu Qingzhu's Gynecology (abbrev. FQG), and to clarify medication characteristics, compatibility rules and correlations of TCMs used in these diseases. Methods: All prescription medications for women's emotional diseases were used for statistical analysis, including the frequency, function and classification of them by Microsoft Excel. Apriori algorithm was used for medication association analysis to find high-frequency drug combinations, and Gephi software was used for network analysis to find core medications and new modules. Results: The top nine high-frequency TCMs included Angelica, Radix Paeoniae Alba, Baizhu, Licorice, Bupleurum, Moutan Bark, Rehmanniae Radix, Ginseng and Black Mustard. According to the function, the most frequently used TCMs were tonic, blood-regulating and heat-clearing drugs. On the basis of classification, we found that the first three medicinal properties were warm, slightly cold, and mild; The first three medicinal flavors were pungent, bitter, and sweet; Highly used meridians were spleen and liver meridians. Eight groups of highly-relevant drug combinations appeared in association analysis. In network analysis, we found eight core drugs and two modules. Conclusion: Our study demonstrates that the treatment in FQG relied mainly on invigoration while elimination subsidiary. And eight core drugs with the meaning of Xiao-Yao-Shan can be used to disperse liver qi, relieve depression, strengthen the spleen and nourish blood. Two new modules can be used for spleen dysfunction in blood governance caused by liver fire and obvious blood deficiency respectively. We hope this article could be helpful for clinical syndrome differentiation and TCM therapy in women's emotional diseases.