Rebound Thymic Hyperplasia in Osteosarcoma After Chemotherapy: ＂Inverted V＂ Phenomenon in the F-18 FDG PET Study

正子影像呈現「倒V字型」：骨癌患者接受化療後引起胸腺反彈性增生

周詩瑾(Shih-Chin Chou) ； 莊紫翎(Tzyy-Ling Chuang) ； 王昱豐(Yuh-Feng Wang)

《核子醫學暨分子影像雜誌》 32卷2期 (2019/06) Pp. 81-84

https://doi.org/10.6332/ANMMI.201906_32(2).0003

摘要

A 14-year-old girl with osteosarcoma of right humerus is under the status of post operation and post chemotherapy. Six months after chemotherapy, an F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) study of whole-body is performed for evaluation of her previous treatment response. In addition to the non-specific radioactivity of the nasopharyngeal area, an ＂inverted V＂ pattern with diffusely increased accumulation of FDG is demonstrated at the mediastinum. This phenomenon represents rebound thymic hyperplasia which was resulted from the effect of recent chemotherapy. Further surgical intervention or chemotherapy is unnecessary in this situation. No imaging evidence of recurrence in the following six months was noted. Clinical history should be reviewed to prevent misinterpretation of rebound thymic hyperplasia as relapsed malignancy.

關鍵字

chemotherapy ； FDG PET ； rebound thymic hyperplasia

並列摘要

本文報告一位14歲肱骨骨癌之女性，手術及化學治療六個月後，進行全身F-18氟化葡萄糖正子斷層攝影檢查（正子攝影）評估療效。雙側鼻咽處看到非特異性氟化葡萄糖攝取外，縱膈腔內可見一處呈「倒V字型」廣泛性攝取，此現象與病人最近接受化療引起胸腺反彈性增生有關，病人不需要後續治療，後續追蹤六個月內之影像亦無復發之情形。正子攝影之判讀，應詳閱其臨床病歷，以避免將胸腺反彈性增生誤判讀為胸腺惡性病灶。

並列關鍵字

化學治療 ； 正子攝影 ； 胸腺反彈性增生