Semiquantification of Tc-99m TRODAT-1 SPECT: Comparison Between DaTQUANT and MRI-Based ROI

鎝-99m TRODAT-1單光子斷層造影半定量分析：DaTQUANT軟體與基於磁振造影圈選方法的比較

Chun-Pang Huang(黃淳邦) ； Yen-Hsiang Chang(張雁翔) ； Pei-Wen Wang(王佩文) ； Shu-Hua Huang(黃淑華) ； Yung-Cheng Huang(黃永成) ； Hong-Jie Chen(陳宏杰) ； Chien-Chin Hsu(徐健欽)

《核子醫學暨分子影像雜誌》 36卷1期 (2023/03) Pp. 14-23

https://doi.org/10.6332/ANMMI.202303_36(1).0002

摘要

Background: Dopamine transporter (DAT) brain single photon emission computed tomography (SPECT) is widely used to evaluate parkinsonian disorders. DaTQUANT (GE Healthcare) is a commercial software and has been validated for I-123 Ioflupane SPECT automatic semiquantification. However, its feasibility of DaTQUANT for Tc-99m TRODAT-1 SPECT semiquantification is unknown. To assess the feasibility, we evaluated the acceptable rate of automatic volume of interest (VOI) placement by DaTQUANT and compared semiquantitative data between DaTQUANT and the magnetic resonance imaging (MRI)-based region of interest (ROI) method in Tc-99m TRODAT-1 SPECT. Methods: This retrospective study (May 2021-July 2021) enrolled 45 patients who underwent Tc-99m TRODAT-1 brain SPECT and brain MRI within 6 months. DaTQUANT used a predefined VOI template to calculate the specific binding ratios (SBRs) of the striatum, caudate nucleus, and putamen. The MRI-based method used manually delineated striatal, caudate, putaminal, and occipital ROIs on MRI and transferred them to SPECT images to calculate the striatal, caudate, and putaminal SBRs. Results: The acceptable rate of automatic VOI by DaTQUANT was 97.8%. The striatal, caudate, and putaminal SBRs were 0.51 ± 0.30, 0.58 ± 0.32, and 0.47 ± 0.31 from DaTQUANT and 0.55 ± 0.31, 0.54 ± 0.32, and 0.55 ± 0.31 from the MRI-based method, respectively. Their concordance correlation coefficients were 0.919, 0.901, and 0.869, respectively. Systemic biases of striatal, caudate, and putaminal SBRs from DaTQUANT were -0.037, 0.038, and -0.077 compared with the MRI-based method. Conclusions: DaTQUANT automatic semiquantification appeared to be feasible in Tc-99m TRODAT-1 SPECT. The semiquantitative SBRs from DaTQUANT correlated well with those from the MRI-based method. However, biases between them are significant; thus, they cannot be used interchangeably.

關鍵字

DaTQUANT ； semiquantification ； Tc-99m TRODAT-1 SPECT

並列摘要

背景：多巴胺轉運體單光子斷層造影廣泛應用於評估帕金森氏疾病。DaTQUANT軟體（奇異公司）已被驗證可使用於碘-123 Ioflupane單光子斷層造影進行自動半定量分析，但此軟體是否也能用於鎝-99m TRODAT-1單光子斷層造影的自動半定量分析仍未知。為了評估其可行性，我們採用人工評估DaTQUANT自動圈選區域的可接受率，並且比較DaTQUANT軟體自動圈選區域與基於磁振造影人工圈選區域的半定量分析數據。方法：本回溯性研究納入了2021年5月到7月間於本院接受鎝-99m TRODAT-1單光子斷層照影且在6個月內也有接受磁振造影的病人共45位。DaTQUANT軟體自動圈選區域使用預設的模板來計算紋狀體、尾狀核與殼核的特異性結合率。人工圈選區域方法則以手繪方式在磁振造影影像上描繪出紋狀體、尾狀核與殼核的區域，再轉移到疊加的單光子斷層造影影像去計算特異性結合率。結果：DaTQUANT軟體在鎝-99mTRODAT-1單光子斷層造影影像上自動圈選區域的可接受率為97.8%。DaTQUANT軟體自動半定量分析的紋狀體、尾狀核和殼核特異性結合率分別是0.51±0.30、0.58±0.32和0.47±0.31，而基於磁振造影人工圈選區域方法半定量分析的特異性結合率分別是0.55±0.31,0.54±0.32和0.55±0.31。兩種方法的一致性相關係數分別是0.919、0.901和0.869。DaTQUANT軟體的自動半定量分析與基於磁振造影的方法相比，其系統性誤差分別是-0.037、0.038和-0.077。結論：DaTQUANT軟體用於鎝-99m TRODAT-1單光子斷層造影自動半定量分析是可行的，其分析的特異性結合率與基於磁振造影的方法有很好的正相關，然而兩種分析方法之間存在系統性偏差，因此其分析數據不宜混用。

並列關鍵字

DaTQUANT ； 半定量分析 ； 鎝-99m TRODAT-1單光子斷層造影