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- OpenAccess
Protective Effects of ＂Solanum Macrocarpon＂ against Air Pollution-Induced Oxidative Stress in Rats: Toxicological and Histopathological Studies
並列摘要
Our study investigated the potential ability of ＂Solanum macrocarpon＂ (African eggplant), used as nutritional supplements, in alleviating toxicity induced by urban air pollution exposure. Male albino Wistar rats were exposed for 63 days either to urban air pollution without treatment (A); oral supplementation with ＂Solanum macrocarpon＂ given at 36 and 75 mg/kg body weight (BW), representing C and D respectively and exposed to air pollution; oral supplementation with ＂Solanum macrocarpon＂ given at 75 mg/kg BW after exposure to air pollution (B); or kept in animal house without exposure to air pollution (E). The exposure of rats to air pollution without treatment promoted oxidative stress with a significant increase in levels of cellular marker enzymes: alanine amino transferase (ALT) and aspatate amino transferase (AST) in serum and homogenates of the exposed animals. Histopathological changes observed show various pathological lesions in all of these tissues except heart caused by exposure to air pollutants. Oral supplementation with ＂Solanum macrocarpon＂ at 75 mg/kg body weight during exposure was able to halt the damage-inducing free radicals produced by air pollutants by reducing the levels of these enzymes leakages in animals. The histopathological findings also confirmed the potential protective effects of ＂Solanum macrocarpon＂ against toxicity induced by exposure to air pollution.
延伸閱讀
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