乳化狀態下製備三醋酸纖維素－乙基纖維素微膠囊

Preparation and Release Behavior of Cellulose Triacetate-Ethylcellulose Microcapsules Containing Theophylline by Using Emulsion Nonsolvent Method

陳暉(Hui Chen) ； 吳貞欽(Jen-Chin Wu) ； 張正倫(Chen-Long Chang)

《化學》 52卷3期 (1994/09) Pp. 301-310

https://doi.org/10.6623/chem.1994040

摘要

本研究探討乳化添加非溶劑法製備水溶性藥物微膠囊時採用三醋酸纖維素－乙基纖維素為殼物質對藥物溶出速率之影響。本實驗選擇茶葉鹼為核物質，二氯甲烷為溶劑，正己烷、環己烷為非溶劑，對不同製程所製備之微膠囊，分析其藥物損失量、微膠囊內藥物含量、粒徑分佈、表面結構、藥物溶出速率及動力學特性。由實駿結果顯示，被物質中三醋酸纖維素之添加量增加，會使得造粒過程中的藥物損失減少，所製得之微膠囊內藥物含量增加及其粒徑變大表面組糙，並且使藥物溶出速率增加。對不同溶劑－非溶劑系統而言，其溶劑與非溶劑之溶解度參數差別念大，則藥物損失量亦增加、微膠囊內藥物含量下降、表面愈光滑並且溶出速率變慢。由本實驗所制備之微膠囊，其制放方式同時符合一階動力去與Higuchi圓球形間質化模式。

關鍵字

微膠囊 ； 三醋酸纖維素 ； 乙基纖維素 ； 乳化添加非溶劑法 ； 溶解度參數

並列摘要

The effect of cellulose triacetate (CTA) as a co-wall material has been discussed by using emulsion nonsolvent addition method to prepare ethylcellulose (EC) microcapsules. The microcapsules were prepared by using theophylline as a core material and dichloromethane-n-hexane and dichlormethanecyclohexane as solvent-nonsolvent pairs. The drug content, drug loss, particle size distribution, surface characteristic, release rate and kinetic characteristic of microcapsules has been discussed. The presence of CTA will affect microcapsules by reducing the drug loss, increasing the value of drug content, enlarging the particle size and bring about the surface irregularity of microcapsules. Furthermore using CTA as co-wall material will increase the release rate of microcapsules. Increasing the difference of solubility parameter between solvent and nonsolvent, microcapsules have higher drug content value, more smooth surface and slower release rate. The microcapsules prepared from different process were profiled first order and Higuchi spherical matrix models.

並列關鍵字

Microcapsules ； Cellulose Triacetate ； Ethylcellulose ； Emulsion Nonsolvent Addition Method ； Solubility Parameter