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多型性腺瘤癌-案例報告及文獻回顧

摘要


多型性腺瘤癌(carcinoma ex pleomorphic adenoma, CXPA)為一種罕見的多形性腺瘤惡性轉變。其癌化風險因子包括:長時間的多型性腺瘤病史體積大、來自小型唾液腺,患者年紀大等等。由於多型性腺瘤癌發生率極低,其標準治療與預後尚未有定論。手術治療為現今的主要治療方式,對於有高風險因子的病人,可考慮術後放射治療。本文以一個44歲女性因20年的右側腮腺瘤病史,而來到門診接受手術治療,病理解剖發現有癌性轉化,因此藉由此案例,來回顧此疾病近期發展與治療。

參考文獻


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Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 2001;32:596-604.
Chandana SR, Conley BA. Salivary gland cancers: current treatments, molecular characteristics and new therapies. Expert Rev Anticancer Ther 2008;8:645-52.
Demasi AP, Furuse C, Soares AB, et al. Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation. Hum Pathol 2009;40:390-7.
Di Palma S. Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol 2013;7:S68-76.

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