In light of Reformed theology and with a special focus on Jurgen Moltmann and Nicholas Wolterstorff, this article aims to expound the notion of "integrity of human life" deriving from the Christian understanding of the relationship between God and human being. This is to engage with the problem of dignity inherent in the disucssion of human rights, and to support the claim of "moral authority" in human rights discussion between different disciplines. For Moltmann, human dignity is embodied in the realization of human destiny as the image of God, which affirms the integrity of human life and God's authority to human being. For Wolterstorff, the belief of the "love of God" implies the respect of human value and development, which grounds the natural human rights and strengthens the moral aspect of human rights law and practice. Moltmann and Wolterstorff's ideas produce the issue of irreducible human dignity and consequently human development and fulfillment. These respond to the moral challenge in contemporary human rights discussion and practice from a theological perspective.