High Dose Intravenous Labetalol for the Resection of Metastatic Pheochromocytoma

高劑量靜注Labetalol於肝臟合併淋巴結轉移之嗜鉻性細胞瘤切除之病例報告

鍾志豪(Peter C.H, Chung) ； 沈青華(Daniel C.W. Sum) ； 吳世銓(Rick S.C. Wu)

《Acta Anaesthesiologica Sinica》 34卷4期 (1996/12) Pp. 235-238

https://doi.org/10.6955/AAS.199612.0235

摘要

A case of intrahepatic metastatic pheochromocytoma with lymph nodes involvement undergoing resection of tumor was reported; intravenous labetalol in high dose regimen (2 mg/kg administered before skin incision) was used for blood pressure control during the operation. Marked sinus bradycardia was noted after receiving total dose of intravenous labetalol, treated with intravenous atropine 0.4 mg. The total operation time was 6.5 h. We found that under isoflurane anesthesia, duration of action of intravenous labetalol was prolonged as adequate intraoperative blood pressure control was obtained throughout the 6-h surgical period without further need of supplementary medication. This finding suggested that duration of labetalol was extended when concomitantly used with isoflurane and the labetalol dosage in our regimen could be effectively used in surgical procudures lasting for more than 6 h.

關鍵字

Paraganglioma: pheochromocytoma ； Antihypertensive agents: labetalol

並列摘要

本文報導一手術時間長達6.5小時之肝臟合併淋巴結轉移之嗜鉻性細胞瘤切除病例，術中成功使用高劑量靜注labetalol作血壓控制（全部labetalol均於皮膚切開前給完）。本報告顯示labetalol以高劑量靜注後，能對長時間以isoflurane麻醉之嗜鉻性細胞瘤切除病例作有效的血壓控制。

並列關鍵字

嗜鉻細胞瘤 ； 抗高血壓劑：labetalol