Reforms of and reflections on general education in colleges of the United States thrived from the end of the First World War to the Second World War. This essay provides a detailed overview of the general education reform led by Joseph Jackson Schwab (1909-1980) from the 1940s to 1960s at the University of Chicago, where he transformed the ideals of Robert Maynard Hutchins et al. into a reality. Schwab devoted himself to expanding the place of science in the general education of undergraduate students and placed particular emphasis on biological sciences. Even though his practices were too hard to continue, his insightful legacy has become a critical point of reference when discussing the ultimate aims and practical methods of general education. Eventually, his latter theoretical "Practical" essays in curriculum studies were partly motivated and then came to mature due to his curriculum deliberation experience with his colleagues at Chicago.