- 期刊
氟化葡萄糖正子檢查受檢者依照體重進行注射活度最適化的有效劑量評估
Evaluation the Effective Dose of Whole-body PET Study with 18F-FDG Injection Activity Optimizes by Body Weight
摘要
臨床上接受氟化去氧葡萄糖（2-deoxy-2-(18F) fluoro-D-glucose，(F-18)FDG）正子攝影的受檢者會因為所給予的(F-18)FDG 放射活度多寡而影響接受的輻射劑量。因此近年來相繼有臨床指引或文獻提供就給予活度進行最適化的方法，我們參照歐洲核醫學會臨床指引在日常工作中依照影像收集條件對應的受檢者體重來進行給予活度的最適化。在本實驗中，我們隨機選擇了2013 年五月份的前100 例受檢者，再比較經過最適化的給予活度與一般組裝活度370MBq 所造成之有效劑量。依據我們的統計，相較於一般直接給予370MBq 的方式，這100 位受檢者中有48 位60.94 公斤以下的受檢者藉由實施依照體重進行給予活度最適化工作而減少平均64.76MBq 的給予活度（平均減少的有效劑量為1.23mSv）且此最適化的工作並且協助我們達到給予活度一致性：平均每公斤體重接受5.51MBq（SD=0.34）。我們並且發現，以60 公斤受檢者為例，使用我們的方式可以將有效劑量減低至5.24mSv，但是若使用2D 收集方式（每區段增至3.5 分鐘）有效劑量可能增加至8.93mSv，這讓我們相信並支持對於一般受檢者進行(F-18) FDG 正子檢查時，使用3D 收集方式且以體重進行給予活度最適化、適時的調整收集時間可以有效的協助大部分的一般受檢者降低有效劑量。
並列摘要
People in the process of (F-18) FDG (2-deoxy-2-(18F) fluoro-D-glucose) positron emission tomography were receiving the radiation dose and it were along with the given radioactivity. Therefore, in recent years, there are many clinical guidelines or literature provides the methods for optimize the given radioactivity of (F-18) FDG. We follow the clinical guidelines of European association of nuclear medicine (EANM) to optimize the given radioactivity in our daily work with our acquisition parameter and the body weight of each case. In this study, we randomly selected the first 100 cases in May 2013, and then compare the different of the effective dose that if with optimize given radioactivity or directly given with the unit dose of FDG which had 370MBq. According to our statistics, if the same subject with body weight of 60 kG,, the effective doses can reduce about 1.05mSv, and more likely to increase to 8.93mSv if using the 2D method to do the scan. It also let us believe that 3D scan method with optimized injection activity by body weight, adjustment the scan time were useful to help reduce the effective dose of 18F FDG PET scan.
延伸閱讀
- 陳淑貞、李冠瑩、蔡惠予、吳志毅（2014）。氟化去氧葡萄糖正子電腦斷層受檢者的劑量長度乘積評估。臺灣醫事放射期刊，2(2)，13-24。https://doi.org/10.6717/JTMRT.201407_2(2).0002
- Wang, M. T., Lee, D. K. T., Wong, C. Y., & Wang, D. P. (1997). Ceftizoxime sodium及Famotidine於5%葡萄糖靜脈注射輸送液中配伍性之研究. Journal of Medical Sciences, 18(1), 29-33. https://www.airitilibrary.com/Article/Detail?DocID=10114564-199708-201306050001-201306050001-29-33
- Chang, P. L., Shen, D. H. Y., Yang, K. T., Hung, G. U., Huang, W. S., Cheng, C. Y., Yu, C. P., Lin, C. K., & Peng, Y. J. (2006). Rosai Dorfman病的氟－18-去氧葡萄糖之正子電腦斷層影像：個案報告. 核子醫學雜誌, 19(4), 265-269. https://doi.org/10.6332/ANMS.1904.007
- Luczynski, W., Fendler, W., Ramatowska, A., Szypowska, A., Szadkowska, A., Mlynarski, W., Chumiecki, M., Chobot, P. J., Chrzanowska, J., Noczynska, A., Brandt, A., Mysliwiec, M., Olszewska, B. G., Bernatowicz, P., Kowalczuk, O., & Bossowski, A. (2014). Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity. International Journal of Endocrinology, 2014(), 328-332-136. https://doi.org/10.1155/2014/630712
- 陳玉玲、黃瑞華、陳玉楚、李鴻森、謝芳傑、湯豐誠（2008）。Evaluation of the Effect of Diet Diary Used in the Work-place Weight-Reduction Program。中華職業醫學雜誌，15(3)，219-226。https://doi.org/10.30027/CJOM.200807.0004