This article should be the first to discuss interpersonal interactions and enterprise competition and cooperation through the integration of the game theory of economics, the framework theory of sociology and the Madhyamika theory of Buddhism. The first example is a zero-sum game, in which managers of two major fund companies use the establishment and transfer of strategic frameworks to engage in a zero-sum game against each other, where one side gains and the other side loses. The second example is to use the Madhyamika of Buddhism to practice self-growth as an observer and also as an observed person. Through the cooperation of the observer and the observed person, a win-win result of the Nash equilibrium game can be achieved.