Objective: To explore the application and effect of rehabilitation nursing in patients with dysphagia after stroke. Methods: 60 patients with dysphagia after stroke admitted to our hospital from August 2016 to October 2018 were randomly divided into control group and observation group, 30 cases in each group. The control group was given routine clinical nursing, while the observation group was given early rehabilitation nursing on the basis of the control group. The nursing effects of the two groups were compared. Results: Compared with the control group, the effective rate of recovery of swallowing dysfunction and ADL score in the observation group were higher, while the scores of NIHSS and Hamilton Depression Scale (HAMD) were lower, with statistical significance (P < 0.05). Conclusion: Rehabilitation nursing for stroke patients with dysphagia can promote the recovery of swallowing function and improve their health status, which is worthy of clinical application.