Because of its advantages of high energy saving, high comfort and low noise, radiation ceiling has become a new type of air conditioning terminal form, but there are problems such as condensation, insufficient cooling capacity and no fresh air. The combination of radiant cooling and displacement ventilation can complement each other and play an important role in the improvement of energy saving and indoor thermal comfort. In this paper, an air conditioning system model with cold radiation ceiling and displacement ventilation is established to simulate the distribution of heat and humidity in the room. Results show that the cold radiation ceiling and displacement ventilation air conditioning system can provide a comfortable environment for indoor, indoor temperature can be maintained in the stable operation of the design temperature of 26°C or so, the workspace temperature gradient is less than 2°C, the indoor thermal comfort index PMV and PPD are within the scope of the comfort, accord with human body comfort requirements.