【論文摘要】The Dose-response Effect of Serum Uric Acid on Incident Metabolic Syndrome in Healthy Individuals

Cheng-Wei Liu

《海峽循環醫學雜誌》 1卷2S期 (2019/09) Pp. 113-115

https://doi.org/10.6907/SCJ.201909/SP_1(2).0092

摘要

Background/Synopsis: Background Elevated serum uric acid is reportedly associated with the prevalence of metabolic syndrome, but limited evidence investigates the dose-response effect of elevated serum uric acid on the incidence of Metabolic syndrome. Objectives/Purpose: The aim of the study is to investigate whether elevated serum uric acid is associated with the incidence of metabolic syndrome in healthy individuals and whether the dose-response effect exists. Methods/Results: Methods We used the database of the annual health exam with a number of 10,537 healthy individuals aged than 30 years in 2016 and 6,389 of them without Metabolic syndrome at baseline underwent the exam between 2017/1/1-2017/12/31. The interest of the study was new-onset metabolic syndrome in 2017. The definition of metabolic syndrome is based on the Taiwan criteria. Hyperuricemia is defined as a serum uric acid level of 7 mg/dl or more in men or 6 mg/dl or more in women. Results The study population consisted of 6,389 individuals with a mean age of 35.8 years (SD 4.7) and a mean body mass index of 24.7 kg/m2 (SD 3.2); 86% of the individuals were men. The prevalence of hyperuricemia was 27.7% at baseline and the incidence rate of metabolic syndrome was 10.1% in the next year. The hyperuricemic group was predominantly male and had a greater ratio of drinking and greater laboratory cardiometabolic biomarker values than did the normouricemic group. In multiple logistic regression analyses, each increment of serum uric acid was associated with increased risks of incident Metabolic syndrome (adjusted OR:1.213, 95% CI:1.124-1.310, P＜0.001). Sensitivity analyses showed consistent results when replacing waist circumference by body mass index (adjusted OR:1.178, 95% CI:1.091-1.273, P＜0.001). Conclusion: We demonstrated that the dose-response effect of elevated serum uric acid is associated with the incidence of metabolic syndrome in healthy individuals from Taiwan. Based on this evidence, future studies should investigate urate-lowering therapy and cardiovascular benefits in individuals with hyperuricemia.