Objective: To evaluate the effect of early comprehensive rehabilitation nursing in the nursing of elderly patients with cerebral infarction hemiplegia and the influence of NIHSS score. Methods: the cases were collected from January 2021 to January 2022. Taking the elderly patients with cerebral infarction hemiplegia treated in our hospital as the investigation target, 76 cases were divided into groups according to the computer random distribution method. The control group received routine nursing and the observation group received early comprehensive rehabilitation nursing. The ability of daily living, motor function, nerve damage and nursing satisfaction of the two groups were evaluated and compared. Results: there was no significant difference between the two groups before nursing. After nursing, the Barthel Index and Fugl-Meyer score of the observation group were significantly higher than those of the control group, and the NIHSS score of the observation group was significantly lower than that of the control group (P < 0.05); The total satisfaction of patients in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: the application of early comprehensive rehabilitation nursing in the nursing of elderly patients with cerebral infarction hemiplegia can not only reduce the degree of nerve damage, but also improve their motor and living ability, and promote their early health, which is worthy of clinical adoption.